Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate Receptors
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Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate Receptors
Ca2+ influx through N-methyl-D-aspartate (NMDA) receptors activates signal transduction pathways critical for many forms of synaptic plasticity in the brain. NMDA receptor-mediated Ca2+ influx also downregulates the gating of NMDA channels through a process called Ca2+-dependent inactivation (CDI). Recent studies have demonstrated that the calcium binding protein calmodulin directly interacts w...
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ژورنال
عنوان ژورنال: Neuron
سال: 1998
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80553-x